n“Small-scale evolution within a species (such as we see in domestic breeding) makes use of variations already present in a population, but large-scale evolution (such as Darwin envisioned) is impossible unless new variations arise from time to time.”, Jonathan Wells, Icons of Evolution, p. 177
nGenes consisting of DNA are the carriers of hereditary information (directs
development)
nNew variations
originate as mutations
nMost mutations
are harmful