Related Resources
(View PowerPoint Presentation)
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The PowerPoint file above was used
during a presentation to the
Design Science Association
in Portland, OR July 2003. The 64 minute audio file is a recording of
that seminar, which is based on a
research paper of the
same title. Follow along with the slideshow while listening. (7.4MB
WAV file)
Windows Media Player Required for Streaming Audio
Genetic Variability by Design - Read the full technical review article published in TJ 18(2) 2004 |
Abstract
New alleles are accumulating rapidly in living populations and cellular mechanisms have not been adequately sought to explain the intentional production of these changes. Homologous DNA recombination occurs in all organisms and is at the heart of genetics. Since its discovery during meiosis, these reactions were assumed to occur randomly along the length of chromosomes, and only involved with gene crossovers. It is now well known that meiotic recombination is not the random process it was originally assumed to be, and controlled by highly organized regulatory systems. In addition, a form of homologous recombination has been discovered which is responsible for creating diversity in variable genes, and was recently linked to single base-pair substitutions in immunoglobulins. New allele formation may indeed be the key to explaining the rapid production of distinct breeds, but their presence in the genome has been assumed the result of random mutations. Therefore, the ability of the cell to purposefully edit genes requires evaluation.
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